Dermatologists from the University of Pennsylvania announced in early 2012 that they have found an enzyme called prostaglandin D2 (PGD2), that, as they say, instructs the hair follicles to stop hair production.
After screening 250 genes associated with hair loss, they came to the conclusion that the one who is responsible for the level of PGD2, played a "major role". In 17 men with hair loss level of PGD2 it was detected three times higher in bald spots than in hairy areas.
If in March in the journal Science Translational Medicine original study was published, George Katsarelis, head of the department of dermatology at the University of Pennsylvania, said: "We really think that if you remove the inhibition (caused by PGD2}, you get more hair."
If the guilty will PGD2, we can note two more reasons:
1. The output can give an answer not only to stop hair loss, but also the fact that bald men grow full of hair
2. There are already drugs that reduce PGD2 levels; The presence of these treatments should help speed up the time it takes to with & # 39 appears in the chemical near you
Hey, here I am trying to be an adult
University of Pennsylvania team first applied the lotion on mice and found that it is effective in hair loss termination, and in the restoration of follicles that have ceased to produce longer hair.
"During normal cyclical follicles in mice Ptgds and PGD2 levels increase immediately before the regression phase, suggesting an inhibitory effect on hair growth," the study said. "We show that PGD2 inhibits hair growth in explaining human hair follicles and the topical application in mice."
Earlier in the same team found that bald men have cells capable of making hair; they just have not been able to ripen.
It is believed that prevents cells PGD2 keep pace. Blocking this action allows the hair to grow again.
Time to market? Sometime during the next phase of anagen
& # 39; Blockers & # 39; Enzyme already been formulated as tablets for the treatment of asthma and allergic conditions. Already there are 10 drugs that block the receptor that allows PGD2 work. They can be converted into a lotion that can be applied to the scalp.
Dr. Katsarelis commented: "The dramatic thing in the field of dermatology and hair loss in general is that you can make the connection, which may be used as a tablet, and to introduce them to the current structure";
In August 2012, he said that talks & # 39; with several pharmaceutical companies to develop treatments and hopes to start clinical trials within two years.
Notwithstanding the foregoing, the research team also noted: "We certainly believe that it would be good in the prevention of hair loss, but we do not know what is the address & # 39;.
It is expected that future studies will investigate whether a protein inhibitor may also help women with androgenetic alopecia (baldness women).
Thus, watch this space …
This is not the first time that Dr. Katsarelis announced breakthrough & # 39; a cure for baldness. Although, of course, an expert in their field, the proof is in the pudding. If it really turns out to something greater than & premature congratulations & # 39; then, in theory, we can only wait for another 1 – 2 years (give or take) to evaluate the results.