Europe and the United States is probably still a year from licensing of gene therapy, but currently there are at least two clinical trials testing gene therapy of mesothelioma. They include the University of Pennsylvania and Louisiana State University. Unfortunately, the study of gene therapy has taken a big blow in 1999 when teenager Jesse Gelsinger died during a clinical trial on gene therapy at the University of Pennsylvania.
Despite this, currently China & # 39 is the only country in the world, which has already approved gene therapy. 16 October 2003, a drug called Gendytsyn was approved by the State Administration of food and medicine in China. For approval gendytsynu been more than 5 years of clinical trials. Currently they are using this therapy in more than 4,500 patients and monitor their patients for over 6 years. Today, hundreds of cancer patients from all over the world come to Beijing to receive this treatment in advanced countries.
In clinical trials Genditsina included 135 patients, and the results showed that 64% of patients showed tumor regression after 8 weekly yn & # 39; ektsy in combination with radiotherapy. According to the results of clinical trials, use Gendytsynu with chemotherapy and radiation therapy can improve efficiency 3 times. The only side effect gendytsynu with 39 & # is the typical temperature overnight.
Because in the world there are no other approved treatments for gene therapy, many desperate cancer patients from North America and Europe are going to Beijing, China to receive treatment gendytsynam.
In Vaysenborna Richard from Texas, USA, it was the tongue cancer that had spread to his lymph nodes, and he was given two months to live in July 2006, about 30 000 US dollars
After two cycles of treatment, within two months, check the pet has shown that he is deprived of cancer. The controversy surrounding this story is that, despite the fact that cancer Richard disappeared, there is some doubt as to whether it was cured chemotherapy or gendytsyn. Dr. Mark Persky, Cancer specialist, noted that "according to my review, there is really no way to tell whether caused by one or another tumor regression."
In a healthy cell of a gene a gene called p53, which can restore DNA halt the growth of cells and initiate the destruction of cells, if cell damage is too large, as in the case of cancer. However, the study of the Chinese Academy of Preventive Medicine in Beijing, they found that there is a high incidence of damage to the gene p53 in cancer related to asbestos, such as mesothelioma.
Gendytsyn acts reaktyvavavshy gene p53, which acts as supresatar tumor, but the cancer cell is excluded because it may deaktyvavatstsa mutagens such as asbestos, chemicals and radiation. gendytsynam treatment using a virus as a medium for transfer of p53 gene in cancer cells and p53 gene is reactive and trigger self-destruction (apoptosis) of the cancer cell.